Rheumatoid Arthritis Current Studies Therapeutic Options and Mechanisms of Action

Dr. Silverman is a practicing rheumatologist and professor of medicine and pathology, Co-Director of the Musculoskeletal Center of Excellence at New York University (NYU) and the Director of the NYU Laboratory of B-Cell Immunobiology. 
 
Dr. Silverman's research group has focused on understanding the immunobiologic origins of B-cell and antibody responses, and dissecting the molecular bases for immune regulation, with a special interest in inflammatory and autoimmune diseases. Ongoing studies are examining the pathogenic features of autoantibodies in rheumatoid arthritis and lupus, and studies of the immunoregulatory properties of protective IgM antibodies that recognize apoptotic cells. He is also investigating the interface between the microbiome, host immune defenses, and the development of autoimmune disease.
 
Dr. Silverman has published over 150 articles in his field. He has received numerous awards from the National Institute of Allergy and Infectious Diseases, the Arthritis Foundation, and the Alliance for Lupus Research. He is an elected member of the American Society for Clinical Investigation, the Henry Kunkel Society, and a past chairman of the Research Program of the Arthritis Foundation.

Dr. Kremer is a graduate of Temple University School of Medicine, where he was elected to the Alpha Omega Alpha honorary society. He completed both a residency in internal medicine and fellowship in rheumatology at the Albany Medical Center Hospital and the Albany Medical College.
 
Between 1979 and 2000, Dr. Kremer served on the fulltime faculty of the Albany Medical College. He was appointed as a full professor of medicine in 1990 and became the Head of the Division of Rheumatology in 1992. In 2000, he became The Director of Research at the Center for Rheumatology, in Albany, New York. In 2005, he became the first Pfaff Family Professor and Chair in Medicine of the Albany Medical College.
 
Dr. Kremer has contributed >200 original articles to the scientific literature. In addition, he has authored 18 book chapters and edited 4 texts on the rheumatic diseases. He has been an invited lecturer at numerous academic institutions throughout this country and internationally. In 1997, he was awarded the Virginia Engalitcheff award of the Arthritis Foundation at a ceremony in Denver, Colorado, for his work on methotrexate in patients with rheumatoid arthritis. The award is given to an individual who has "improved the quality of life of patients with arthritis over the past ten years."